N²,N³-bis (tert-butoxycarbonyl)-N¹-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine

Base Information

• Chemical Name: N²,N³-bis (tert-butoxycarbonyl)-N¹-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine
• CAS No.: 1627500-55-3
• Molecular Formula: C₃₄H₄₃Br₂ClN₄O₉
• Molecular Weight: 846.998

Synonyms:N²,N³-bis (tert-butoxycarbonyl)-N¹-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine

Chemical Property of N²,N³-bis (tert-butoxycarbonyl)-N¹-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine

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Technology Process of N²,N³-bis (tert-butoxycarbonyl)-N¹-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine

There total 6 articles about N²,N³-bis (tert-butoxycarbonyl)-N¹-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

C15H23NO2 + N2,N3-bis(tert-butoxycarbonyl)-N1-(4-oxy-3-chlorobutyl)guanidine (1627500-54-2) + 3-(3,5-dibromo-4-methoxyphenyl)-2-oxopropanoyl chloride (1627500-52-0) → N2,N3-bis (tert-butoxycarbonyl)-N1-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine (1627500-55-3)

Guidance literature:

C₁₅H₂₃NO₂; N²,N³-bis(tert-butoxycarbonyl)-N¹-(4-oxy-3-chlorobutyl)guanidine; With magnesium sulfate; In dichloromethane; at 20 ℃; for 0.5h;

3-(3,5-dibromo-4-methoxyphenyl)-2-oxopropanoyl chloride; In dichloromethane; chloroform; at 20 ℃; for 16h;

DOI:10.1002/anie.201402310

Reference yield:

2,3-di(tert-butoxycarbonyl)-1-(4-oxobutyl)guanidine (1221492-46-1) → N2,N3-bis (tert-butoxycarbonyl)-N1-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine (1627500-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: L-proline / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 0.5 h / 20 °C

2.2: 16 h / 20 °C

With magnesium sulfate; L-proline; In dichloromethane;

DOI:10.1002/anie.201402310

Reference yield:

N,N'-bis-Boc-S-methyl-isothiourea (322474-21-5) → N2,N3-bis (tert-butoxycarbonyl)-N1-(3-chloro-5-((Z)-3,5-dibromo-4-methoxybenzylidene)-3-((2,4-dimethoxybenzyl)-4-oxooxazolidin-2-yl)propyl)guanidine (1627500-55-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 h / 50 °C

2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 1.33 h / -78 - 20 °C / Inert atmosphere

3.1: L-proline / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: magnesium sulfate / dichloromethane / 0.5 h / 20 °C

4.2: 16 h / 20 °C

With oxalyl dichloride; magnesium sulfate; triethylamine; L-proline; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/anie.201402310

upstream raw materials:

N²,N³-bis(tert-butoxycarbonyl)-N¹-(4-oxy-3-chlorobutyl)guanidine

3-(3,5-dibromo-4-methoxyphenyl)-2-oxopropanoyl chloride

N,N'-bis-Boc-S-methyl-isothiourea

N²,N³-bis(tert-butoxycarbonyl)-N¹-(4-hydroxybutyl)guanidine

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