(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Base Information

Chemical Name:(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester
CAS No.:956320-15-3
Molecular Formula:C₁₇H₁₉Cl₂F₃N₂O₅S
Molecular Weight:491.315
Hs Code.:

Synonyms:(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Suppliers and Price of (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

There total 8 articles about (R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 956320-16-4
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 358-23-6
trifluoromethylsulfonic anhydride

: 956320-15-3
(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Guidance literature:: With dmap; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 956320-15-3
(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 4 h / 20 °C

5.1: dmap / dichloromethane / 3 h / 0 - 20 °C

With dmap; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; sodium nitrite; palladium hydroxide on carbon; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; water; ethyl acetate;

Reference yield:

: 956320-30-2
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 956320-15-3
(R)-trifluoro-methanesulfonic acid 3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 4 h / 20 °C

2: dmap / dichloromethane / 3 h / 0 - 20 °C

With dmap; hydrogen; palladium hydroxide on carbon; In dichloromethane; ethyl acetate;