4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

Base Information

Chemical Name:4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
CAS No.:1380333-95-8
Molecular Formula:C₂₃H₂₀ClN₅O₂S
Molecular Weight:465.963
Hs Code.:

Synonyms:4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

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Chemical Property of 4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

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Technology Process of 4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

There total 5 articles about 4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1380333-86-7
8-iodo-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 619-56-7
4-chlorobenzamide

: 1380333-95-8
4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 4h; Inert atmosphere;
DOI:10.1002/ejoc.201200168

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1380333-95-8
4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethyl acetate / Acidic conditions

2.1: triethylamine / butan-1-ol / 5 h / 60 °C

3.1: diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; ethyl acetate; triethylamine; diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; butan-1-ol;
DOI:10.1002/ejoc.201200168

Reference yield:

: 1380333-85-6
6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1380333-95-8
4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1002/ejoc.201200168