(E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

Base Information

Chemical Name:(E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide
CAS No.:1259519-20-4
Molecular Formula:C₂₆H₂₅N₅O₂
Molecular Weight:439.517
Hs Code.:

Synonyms:(E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

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Chemical Property of (E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

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Technology Process of (E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

There total 4 articles about (E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 1246087-09-1
3-cyano-6-amino-7-ethoxy-4-(3-ethynylanilino)quinoline

: 1130155-48-4
(E)-4-(dimethylamino)-2-butenoic acid hydrochloride

: 1259519-20-4
(E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

Guidance literature:: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride; With oxalyl dichloride; In tetrahydrofuran; at 30 ℃; for 4h;

3-cyano-6-amino-7-ethoxy-4-(3-ethynylanilino)quinoline; In tetrahydrofuran; at 10 ℃; for 12h; Temperature; Reagent/catalyst; Solvent;

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1259519-20-4
(E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid / N,N-dimethyl-formamide / 10 h / 90 °C

2.1: hydrogenchloride / water / 22 h / 80 °C

3.1: oxalyl dichloride / tetrahydrofuran / 4 h / 30 °C

3.2: 12 h / 10 °C

With hydrogenchloride; oxalyl dichloride; trifluorormethanesulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1259519-60-2
4-dimethylaminocrotonic acid methyl ester hydrochloride

: 1259519-20-4
(E)-N-{[4-(3-ethynylphenylamino)-3-cyano-7-ethoxy-6-quinolyl]}-4-(dimethylamino)-2-butenoic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.5 h / 0 °C / Reflux

1.2: 1 h / 0 °C / pH 2

2.1: oxalyl dichloride / tetrahydrofuran / 4 h / 30 °C

2.2: 12 h / 10 °C

With oxalyl dichloride; sodium hydroxide; In tetrahydrofuran; water;