3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate
CAS No.:1360592-71-7
Molecular Formula:C₄₁H₅₅O₃PSi
Molecular Weight:654.945
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

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Chemical Property of 3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

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Technology Process of 3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

There total 5 articles about 3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1360592-57-9
2-((tert-butyldimethylsilyloxy)(cyclohexyl)methyl)-1-cyclohexylprop-2-ene-1-ol

: 17261-28-8
ortho-diphenylphosphinobenzoic acid

: 1360592-71-7
3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

Guidance literature:: 2-((tert-butyldimethylsilyloxy)(cyclohexyl)methyl)-1-cyclohexylprop-2-ene-1-ol; With sodium hydride; In diethyl ether; mineral oil; at 20 ℃;

ortho-diphenylphosphinobenzoic acid; With dmap; sodium hydride; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane; at 20 ℃; optical yield given as %de;
DOI:10.1002/chem.201100843

Reference yield:

: 1360592-56-8
1,3-dicyclohexyl-2-methylenepropan-1,3-diol

: 1360592-71-7
3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

2.1: sodium hydride / diethyl ether; mineral oil / 20 °C

2.2: 20 °C

With 1H-imidazole; sodium hydride; In diethyl ether; dichloromethane; mineral oil;
DOI:10.1002/chem.201100843

Reference yield:

: 4352-44-7
1-cyclohexylprop-2-en-1-ol

: 1360592-71-7
3-(tert-butyldimethylsilyloxy)-1,3-dicyclohexyl-2-methylenpropyl 2-(diphenylphosphanyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: 0.25 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

3.1: sodium hydride / diethyl ether; mineral oil / 20 °C

3.2: 20 °C

With 1H-imidazole; lithium; sodium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; mineral oil;
DOI:10.1002/chem.201100843