Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

Base Information

Chemical Name:Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂
CAS No.:845623-04-3
Molecular Formula:C₄₁H₅₃N₅O₇
Molecular Weight:727.901
Hs Code.:

Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH<sub>2</sub>

Synonyms:Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

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Chemical Property of Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

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Technology Process of Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

There total 8 articles about Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3228-03-3
3-isopropyl-5-methylphenol

: 845623-04-3
Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: KIO₃; KI; aq. HCl / methanol / 0.5 h / 20 °C

1.2: pyridine / 0.5 h / 50 °C

2.1: 2.73 g / tri-o-tolylphosphine; TEA; Pd(OAc)2 / acetonitrile / 10 h / Heating

3.1: H₂ / [Rh(1,5-COD)(R,R-DIPAMP)]BF₄ / ethyl acetate / 12 h / 60 °C / 3102.89 Torr

4.1: 0.6 g / aq. HCl / 5 h / Heating

5.1: 95 percent / TEA / dioxane; H₂O / 2.25 h / 0 - 20 °C

6.1: 214 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; palladium diacetate; potassium iodate; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; potassium iodide; [Rh((R,R)-DIPAMP)(COD)]BF₄; In 1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 2.1: Heck reaction;
DOI:10.1021/jm049384k

Reference yield:

: 845622-65-3
4-iodo-3-isopropyl-5-methylphenol acetate

: 845623-04-3
Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

Guidance literature:: Multi-step reaction with 5 steps

1: 2.73 g / tri-o-tolylphosphine; TEA; Pd(OAc)2 / acetonitrile / 10 h / Heating

2: H₂ / [Rh(1,5-COD)(R,R-DIPAMP)]BF₄ / ethyl acetate / 12 h / 60 °C / 3102.89 Torr

3: 0.6 g / aq. HCl / 5 h / Heating

4: 95 percent / TEA / dioxane; H₂O / 2.25 h / 0 - 20 °C

5: 214 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; palladium diacetate; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; [Rh((R,R)-DIPAMP)(COD)]BF₄; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1: Heck reaction;
DOI:10.1021/jm049384k

Reference yield:

: 845622-71-1
methyl (Z)-2-acetamido-3-(4-acetoxy-2-isopropyl-6-methylphenyl)-propenoate

: 845623-04-3
Boc-(2'-isopropyl-6'-methyltyrosine)-Pro-Phe-Phe-NH₂

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / [Rh(1,5-COD)(R,R-DIPAMP)]BF₄ / ethyl acetate / 12 h / 60 °C / 3102.89 Torr

2: 0.6 g / aq. HCl / 5 h / Heating

3: 95 percent / TEA / dioxane; H₂O / 2.25 h / 0 - 20 °C

4: 214 mg / DIPEA; PyBop / dimethylformamide / 4 h / 20 °C

With hydrogenchloride; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; [Rh((R,R)-DIPAMP)(COD)]BF₄; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm049384k