1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

Base Information

Chemical Name:1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol
CAS No.:671232-70-5
Molecular Formula:C₂₂H₃₀O₃Si
Molecular Weight:370.564
Hs Code.:

Synonyms:1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

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Chemical Property of 1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

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Technology Process of 1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

There total 4 articles about 1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(2S,3S)-3-(2-Benzyloxy-propyl)-oxiranylmethoxy]-tert-butyl-diphenyl-silane

: 671232-70-5
1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; ethyl acetate; at 20 ℃; for 1h; under 1520 Torr;
DOI:10.1016/j.tet.2003.09.070

Reference yield:

: 671232-62-5
[(2S,3S)-3-(2-Benzyloxy-propyl)-oxiranyl]-methanol

: 671232-70-5
1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP; Et₃N / CH₂Cl₂ / 3 h / 20 °C

2: 500 mg / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 1 h / 20 °C / 1520 Torr

With dmap; hydrogen; triethylamine; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2003.09.070

Reference yield:

: 671232-61-4
(E)-5-Benzyloxy-hex-2-en-1-ol

: 671232-70-5
1-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-oxiranyl]-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: (+)-DET; Ti(O-iPr)4; 4 Angstroem molecular sieves / CH₂Cl₂ / -20 °C

1.2: 96 percent / TBHP / CH₂Cl₂; toluene / -20 °C

2.1: DMAP; Et₃N / CH₂Cl₂ / 3 h / 20 °C

3.1: 500 mg / H₂ / Pd(OH)2/C / methanol; ethyl acetate / 1 h / 20 °C / 1520 Torr

With titanium(IV) isopropylate; dmap; diethyl (2R,3R)-tartrate; 4 A molecular sieve; hydrogen; triethylamine; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tet.2003.09.070