8-Amino-6-fluoro-9-ribofuranosyl-9H-purine

Base Information

Chemical Name:8-Amino-6-fluoro-9-ribofuranosyl-9H-purine
CAS No.:97229-54-4
Molecular Formula:C₁₀H₁₂FN₅O₄
Molecular Weight:285.235
Hs Code.:
DSSTox Substance ID:DTXSID10914048
ChEMBL ID:CHEMBL611236
Mol file:97229-54-4.mol

Synonyms:6-AFRFP;6-fluoro-9-beta-D-ribofuranosyl-9H-purin-8-amine;8-amino-6-fluoro-9-ribofuranosyl-9H-purine

Suppliers and Price of 8-Amino-6-fluoro-9-ribofuranosyl-9H-purine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 8-Amino-6-fluoro-9-ribofuranosyl-9H-purine

Chemical Property:

Vapor Pressure:1.57E-18mmHg at 25°C
Boiling Point:663.9°Cat760mmHg
Flash Point:355.3°C
PSA：139.54000
Density:2.17g/cm³
LogP:-1.25970
XLogP3:-0.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:285.08733204
Heavy Atom Count:20
Complexity:367

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=NC2=C(C(=N1)F)N=C(N2C3C(C(C(O3)CO)O)O)N
Isomeric SMILES:C1=NC2=C(C(=N1)F)N=C(N2C3[C@@H]([C@@H]([C@H](O3)CO)O)O)N

Technology Process of 8-Amino-6-fluoro-9-ribofuranosyl-9H-purine

There total 2 articles about 8-Amino-6-fluoro-9-ribofuranosyl-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103904-90-1
8-amino-6-fluoro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

: 97229-54-4
8-amino-6-fluoro-9-β-D-ribofuranosyl-9H-purine

Guidance literature:: With ammonia; In ethanol; Yield given; Ambient temperature;
DOI:10.1021/jm00160a046

Reference yield:

: 23205-65-4
2',3',5'-tri-O-acetyl-8-aminoadenosine

: 97229-54-4
8-amino-6-fluoro-9-β-D-ribofuranosyl-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen fluoride-pyridine, NaNO₂ / various solvent(s) / 1.) -25 to -30 deg C, 1.5 h, 2.) 0 deg C, 15 min

2: NH₃ / ethanol / Ambient temperature

With ammonia; pyridine hydrogenfluoride; sodium nitrite; In ethanol;
DOI:10.1021/jm00160a046