1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

Base Information

Chemical Name:1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide
CAS No.:908005-20-9
Molecular Formula:C₃₁H₃₂N₄O₅
Molecular Weight:540.619
Hs Code.:

1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-<i>d</i>][1,3]dioxol-4-ylmethyl)-1<i>H</i>-[1,2,4]triazole-3-carboxylic acid amide

Synonyms:1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

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Chemical Property of 1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

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Technology Process of 1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

There total 8 articles about 1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 908005-19-6
1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid methyl ester

: 908005-20-9
1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 24h;
DOI:10.1081/NCN-200059368

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 908005-20-9
1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / SnCl₄ / CH₂Cl₂ / 3 h / Heating

2.1: methanol

2.2: 75 percent / Dowex 50 H⁺; H₂O / methanol / 5 h / 20 °C

3.1: 65 percent / p-TsOH / acetone / 20 °C

4.1: 62 percent / pyridine / 48 h / 20 °C

5.1: 96 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 0 °C

6.1: 77 percent / DMAP / CH₂Cl₂ / 20 °C

7.1: 56 percent / DBU / acetonitrile / Heating

8.1: 96 percent / ammonia / methanol / 24 h / 20 °C

With pyridine; dmap; lithium aluminium tetrahydride; ammonia; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; tin(IV) chloride; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1081/NCN-200059368

Reference yield:

: 188125-92-0
6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid methyl ester

: 908005-20-9
1-(2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl)-1H-[1,2,4]triazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / 48 h / 20 °C

2: 96 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 0 °C

3: 77 percent / DMAP / CH₂Cl₂ / 20 °C

4: 56 percent / DBU / acetonitrile / Heating

5: 96 percent / ammonia / methanol / 24 h / 20 °C

With pyridine; dmap; lithium aluminium tetrahydride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1081/NCN-200059368