4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid

Base Information

• Chemical Name: 4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid
• CAS No.: 86798-53-0
• Molecular Formula: C₁₄H₁₄N₂O₄
• Molecular Weight: 274.276
• Mol file: 86798-53-0.mol

Synonyms:4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid

Chemical Property of 4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid

There total 1 articles about 4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(1H-imidazol-4-yl)methanol (822-55-9) + 4-(4-fluorophenyl)-4-oxopropionic acid (366-77-8) → 4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid (86798-53-0)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; toluene; 1.) RT, overnight, 2.) 100-110 deg C, 18 h;

DOI:10.1021/jm00148a006

Reference yield: 22.0%

4-(4-hydroxymethyl-1H-imidazol-1-yl)-γ-oxobenzenebutanoic acid (86798-53-0) → 4,5-dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone (86798-54-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Heating;

DOI:10.1021/jm00148a006

upstream raw materials:

(1H-imidazol-4-yl)methanol

4-(4-fluorophenyl)-4-oxopropionic acid

Downstream raw materials:

4,5-dihydro-6-[4-(4-hydroxymethyl-1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone