1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate

Base Information

• Chemical Name: 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate
• CAS No.: 1360651-31-5
• Molecular Formula: C₂₃H₁₇NO₃
• Molecular Weight: 355.393
• Mol file: 1360651-31-5.mol

Synonyms:1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate

Chemical Property of 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate

There total 4 articles about 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(methoxycarbamoyl)phenyl acetate (1354694-09-9) + diphenyl acetylene (501-65-5) → 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate (1360651-31-5)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate; In methanol; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1002/chem.201102445

Reference yield: 72.0%

Acetic acid 4-(naphthalen-1-ylcarbamoyl)-phenyl ester + diphenyl acetylene (501-65-5) → 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate (1360651-31-5)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In 1,2-dichloro-ethane; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/cctc.201500410

Reference yield:

4-acetoxybenzoyl chloride (27914-73-4) → 1-oxo-3,4-diphenyl-1,2-dihydroisoquinolin-6-yl acetate (1360651-31-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water; ethyl acetate / 8 h / 0 - 20 °C / Inert atmosphere

2: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate / methanol / 8 h / 20 °C / Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate; potassium carbonate; In methanol; water; ethyl acetate;

DOI:10.1002/chem.201102445

upstream raw materials:

4-acetoxybenzoyl chloride

4-(methoxycarbamoyl)phenyl acetate

diphenyl acetylene

4-acetyloxy-benzoic acid