7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Base Information

Chemical Name:7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine
CAS No.:227747-41-3
Molecular Formula:C₂₁H₂₆N₄O₂
Molecular Weight:366.463
Hs Code.:

Synonyms:7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

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Technology Process of 7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

There total 2 articles about 7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 227747-37-7
4-(7-chloro-4-phenyl-[1,8]naphthyridin-2-yl)-piperazine-1-carboxylic acid ethyl ester

: 227747-41-3
7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: With hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; at 60 ℃; for 16h; under 1520 Torr;
DOI:10.1016/S0014-827X(98)00094-9

Reference yield:

: 199983-17-0
4-(7-Hydroxy-4-phenyl-[1,8]naphthyridin-2-yl)-piperazine-1-carboxylic acid ethyl ester

: 227747-41-3
7-(4-Carbethoxypiperazin-1-yl)-5-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / POCl₃ / 80 °C

2: 85 percent / H₂, AcONa, AcOH / 10 percent Pd/C / 16 h / 60 °C / 1520 Torr

With hydrogen; sodium acetate; acetic acid; trichlorophosphate; palladium on activated charcoal;
DOI:10.1016/S0014-827X(98)00094-9