(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Base Information

Chemical Name:(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol
CAS No.:183800-60-4
Molecular Formula:C₁₅H₁₉F₂N₃O₃S
Molecular Weight:359.397
Hs Code.:

Synonyms:(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

There total 3 articles about (2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 183800-59-1
(2R,3R)-2-(2,4-difluorophenyl)-3-[(trans-2-phenyl-1,3-dioxan-5-yl)thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 183800-60-4
(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 0.5h;
DOI:10.1248/cpb.48.694

Reference yield:

: 329744-44-7
4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile

: 183800-60-4
(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 329744-59-4
3-fluoro-4-[(1E,3E)-5-oxopenta-1,3-dien-1-yl]-benzonitrile

Guidance literature:: With hydrogenchloride; In water; acetonitrile; at 25 ℃; for 1h;
DOI:10.1002/jps.23339

Reference yield:

: 32295-56-0
S-(trans-2-phenyl-1,3-dioxane-5-yl) thioacetate

: 183800-60-4
(2R,3R)-2-(2,4-difluorophenyl)-3-[[2-hydroxy-1-(hydroxymethyl)ethyl]thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / NaOMe / dimethylformamide / 2 h / 65 °C

2: 88 percent / 4 M HCl; MeOH / dioxane / 0.5 h / 20 °C

With hydrogenchloride; methanol; sodium methylate; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Condensation / 2: Ring cleavage;
DOI:10.1248/cpb.48.694