O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose

Base Information

• Chemical Name: O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose
• CAS No.: 116181-93-2
• Molecular Formula: C₅₂H₆₃NO₁₄
• Molecular Weight: 926.071
• Mol file: 116181-93-2.mol

Synonyms:O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose

Chemical Property of O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose

There total 18 articles about O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose (120308-58-9) → O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose (116181-93-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); triphenylstannane; In toluene; for 2h; Heating;

DOI:10.1016/S0040-4020(01)97586-6

Reference yield: 82.0%

O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose (116096-68-5) → O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose (116181-93-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 0.25h; Heating;

DOI:10.1016/S0040-4020(01)97586-6

Reference yield:

methyl 5-acetamido-4,7,8,9-tetra-O-benzyl-2,3-dehydro-3,5-dideoxy-D-glycero-D-galacto-2-nonulopyranosonate (116096-63-0) → O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose (116181-93-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 8 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 0.5 h / 0 °C

2: 88 percent / diethylaminosulfur trifluoride / toluene; 1,2-dichloro-ethane / 40 °C

3: 42 percent / n-Bu₃SnOTf, molecular sieves 4 A / CCl₄ / 16 h / Ambient temperature

4: 82 percent / n-Bu₃SuH, AIBN / toluene

With 2,2'-azobis(isobutyronitrile); diethylamino-sulfur trifluoride; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; n-Bu₃SuH; tributylstannyl trifluoromethanesulfonate; In tetrachloromethane; 1,2-dichloro-ethane; toluene;

DOI:10.1016/S0040-4039(00)61852-X

upstream raw materials:

O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose

O--(2->6)-1,2;3,4-di-O-isopropylidene-α-D-galactopyranose

2,3-dehydro-2-deoxy-N-acetylneuraminic acid

5-acetamido-4,7,8,9-tetra-O-benzyl-2,3-dehydro-3,5-dideoxy-D-glycero-D-galacto-2-nonulopyranosonic acid