(Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

Base Information

Chemical Name:(Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid
CAS No.:1450915-12-4
Molecular Formula:C₃₇H₂₄BrN₃O₃S
Molecular Weight:670.586
Hs Code.:

Synonyms:(Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

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Chemical Property of (Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

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Technology Process of (Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

There total 4 articles about (Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450915-10-2
(Z)-methyl 6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinate

: 1450915-12-4
(Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/ol401527a

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1450915-12-4
(Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 1 h / 0 - 5 °C

2: hydrazine hydrate / 6 h / 140 °C

3: piperidine / ethanol / 6 h / Reflux

4: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

5: sodium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

With piperidine; copper peroxide; water; bromine; hydrazine hydrate; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; 2: |Wolff-Kishner Reduction / 3: |Knoevenagel Condensation / 4: |Ullmann Condensation;
DOI:10.1021/ol401527a

Reference yield:

: 20870-78-4
5-bromo-2-indolin-2-one

: 1450915-12-4
(Z)-6-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / ethanol / 6 h / Reflux

2: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

3: sodium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

With piperidine; copper peroxide; water; sodium hydroxide; In tetrahydrofuran; ethanol; 1: |Knoevenagel Condensation / 2: |Ullmann Condensation;
DOI:10.1021/ol401527a