C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

Base Information

Chemical Name:C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆
CAS No.:261156-88-1
Molecular Formula:C₃₀H₄₉NO₈SSi
Molecular Weight:611.872
Hs Code.:

C<sub>15</sub>H<sub>28</sub>NO<sub>3</sub>SiC<sub>3</sub>H<sub>5</sub>C<sub>5</sub>H<sub>8</sub>O<sub>2</sub>H<sub>2</sub>OSO<sub>2</sub>C<sub>7</sub>H<sub>6</sub>

Synonyms:C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

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Chemical Property of C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

There total 20 articles about C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261156-79-0
(E)-3-[(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acrylonitrile

: 261156-88-1
C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

Guidance literature:: Multi-step reaction with 12 steps

1.1: 98 percent / H₂ / Pd/C / ethyl acetate / 12 h / 760.05 Torr

2.1: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

3.1: 84 percent / Jones reagent / acetone / 0.5 h / 20 °C

4.1: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

5.1: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

6.1: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

7.1: Na; naphthalene / 1,2-dimethoxy-ethane / 0.25 h / -78 °C

8.1: 1.2 g / DMAP / acetonitrile / 0 - 20 °C

9.1: NaNO₂; CuCl; HCl / methanol / 0.25 h / 20 °C

9.2: allyltrimethylsilane; BF₃*Et₂O / tetrahydrofuran; diethyl ether / -78 - -5 °C

10.1: 180 mg / Et₃N / CH₂Cl₂ / 14 h / Heating

11.1: BH₃*THF; 2-methyl-2-butene / tetrahydrofuran; diethyl ether / 0 - 20 °C

11.2: H₂O₂; aq. NaOH / tetrahydrofuran; diethyl ether / 0.83 h / 20 °C

12.1: 164 mg / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; methanol; dmap; jones reagent; samarium diiodide; borane-THF; 2-methyl-but-2-ene; naphthalene; tetrabutyl ammonium fluoride; hydrogen; sodium; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) chloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; ethyl acetate; acetone; acetonitrile; benzene; 1.1: Catalytic hydrogenation / 2.1: desilylation / 3.1: Oxidation / 4.1: Cyclization / 5.1: Condensation / 6.1: cyclocondensation / 7.1: Reduction / 8.1: Acylation / 9.1: Oxidation / 9.2: Substitution / 10.1: Acylation / 11.1: hydroboration / 11.2: Oxidation / 12.1: Tosylation;
DOI:10.1021/jo000260z

Reference yield:

: 261156-80-3
3-[(R)-4-Oxo-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

: 261156-88-1
C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

Guidance literature:: Multi-step reaction with 9 steps

1.1: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

2.1: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

3.1: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

4.1: Na; naphthalene / 1,2-dimethoxy-ethane / 0.25 h / -78 °C

5.1: 1.2 g / DMAP / acetonitrile / 0 - 20 °C

6.1: NaNO₂; CuCl; HCl / methanol / 0.25 h / 20 °C

6.2: allyltrimethylsilane; BF₃*Et₂O / tetrahydrofuran; diethyl ether / -78 - -5 °C

7.1: 180 mg / Et₃N / CH₂Cl₂ / 14 h / Heating

8.1: BH₃*THF; 2-methyl-2-butene / tetrahydrofuran; diethyl ether / 0 - 20 °C

8.2: H₂O₂; aq. NaOH / tetrahydrofuran; diethyl ether / 0.83 h / 20 °C

9.1: 164 mg / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; methanol; dmap; samarium diiodide; borane-THF; 2-methyl-but-2-ene; naphthalene; sodium; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) chloride; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; acetonitrile; benzene; 1.1: Cyclization / 2.1: Condensation / 3.1: cyclocondensation / 4.1: Reduction / 5.1: Acylation / 6.1: Oxidation / 6.2: Substitution / 7.1: Acylation / 8.1: hydroboration / 8.2: Oxidation / 9.1: Tosylation;
DOI:10.1021/jo000260z

Reference yield:

: 261157-04-4
3-[(2R,4R)-4-Hydroxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-propionitrile

: 261156-88-1
C₁₅H₂₈NO₃SiC₃H₅C₅H₈O₂H₂OSO₂C₇H₆

Guidance literature:: Multi-step reaction with 10 steps

1.1: 84 percent / Jones reagent / acetone / 0.5 h / 20 °C

2.1: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

3.1: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

4.1: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

5.1: Na; naphthalene / 1,2-dimethoxy-ethane / 0.25 h / -78 °C

6.1: 1.2 g / DMAP / acetonitrile / 0 - 20 °C

7.1: NaNO₂; CuCl; HCl / methanol / 0.25 h / 20 °C

7.2: allyltrimethylsilane; BF₃*Et₂O / tetrahydrofuran; diethyl ether / -78 - -5 °C

8.1: 180 mg / Et₃N / CH₂Cl₂ / 14 h / Heating

9.1: BH₃*THF; 2-methyl-2-butene / tetrahydrofuran; diethyl ether / 0 - 20 °C

9.2: H₂O₂; aq. NaOH / tetrahydrofuran; diethyl ether / 0.83 h / 20 °C

10.1: 164 mg / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; methanol; dmap; jones reagent; samarium diiodide; borane-THF; 2-methyl-but-2-ene; naphthalene; sodium; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; copper(l) chloride; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; acetone; acetonitrile; benzene; 1.1: Oxidation / 2.1: Cyclization / 3.1: Condensation / 4.1: cyclocondensation / 5.1: Reduction / 6.1: Acylation / 7.1: Oxidation / 7.2: Substitution / 8.1: Acylation / 9.1: hydroboration / 9.2: Oxidation / 10.1: Tosylation;
DOI:10.1021/jo000260z