N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

Base Information

Chemical Name:N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide
CAS No.:869858-75-3
Molecular Formula:C₂₃H₁₇N₇O₆
Molecular Weight:487.431
Hs Code.:

<i>N</i>-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

Synonyms:N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

Suppliers and Price of N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

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Chemical Property of N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

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Technology Process of N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

There total 1 articles about N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 331806-98-5
2-(N-benzoyl)-amino-5-amino-pyrimidine

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 4316-93-2
4,6-dichloro-5-nitropyrimidine

: 869858-75-3
N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

Guidance literature:: 2-Hydroxy-4-methoxybenzaldehyde; 4,6-dichloro-5-nitropyrimidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h;

2-(N-benzoyl)-amino-5-amino-pyrimidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.tetlet.2005.08.161

Reference yield:

: 869858-75-3
N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

: 869858-76-4
N-[5-(7-methoxy-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-ylamino)-pyrimidin-2-yl]-benzamide

Guidance literature:: N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide; With hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; at 20 ℃; for 12h;

With orthoformic acid triethyl ester; In 1,2-dimethoxyethane; at 20 ℃; for 5h;
DOI:10.1016/j.tetlet.2005.08.161

Reference yield:

: 869858-75-3
N-{5-[6-(2-formyl-5-methoxy-phenoxy)-5-nitro-pyrimidin-4-ylamino]-pyrimidin-2-yl}-benzamide

: N-[5-(7-methoxy-10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-ylamino)-pyrimidin-2-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / 1,2-dimethoxy-ethane / 12 h / 20 °C

1.2: 226 mg / HC(OEt)3 / 1,2-dimethoxy-ethane / 5 h / 20 °C

2.1: 66 percent / NaCNBH₃ / tetrahydrofuran / 1 h / 20 °C

With hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/j.tetlet.2005.08.161