(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

Base Information

Chemical Name:(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide
CAS No.:137301-79-2
Molecular Formula:C₄₂H₄₂ClF₃N₄O₇S
Molecular Weight:839.332
Hs Code.:

(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

Synonyms:(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

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Chemical Property of (2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

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Technology Process of (2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

There total 19 articles about (2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 137301-79-2
(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

Guidance literature:: Multi-step reaction with 8 steps

1: CDI / tetrahydrofuran

2: 1.) Mg / 1.) THF, reflux, 3.5 h, 2.) THF, RT, 15 min

3: 79 percent / NaBH₄ / methanol

4: 83.5 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

6: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

7: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

8: Dess-Martin periodinane reagent, CF₃COOH / CH₂Cl₂ / 16 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 137301-79-2
(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Mg / 1.) THF, reflux, 3.5 h, 2.) THF, RT, 15 min

2: 79 percent / NaBH₄ / methanol

3: 83.5 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

4: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

5: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

6: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

7: Dess-Martin periodinane reagent, CF₃COOH / CH₂Cl₂ / 16 h / Ambient temperature

With sodium tetrahydroborate; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00082a005

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 137301-79-2
(2S)-<<4-<<<(4-chlorophenyl)sulfonyl>amino>carbonyl>phenyl>oxomethyl>-L-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-<2-<3-methyl-1-<4-(trifluoromethyl)phenyl>-1-oxobutyl>>amide

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / CH₂Cl₂ / 16 h / Ambient temperature

2: 1 aq. KOH / ethanol / 16 h / Ambient temperature

3: 1.) CDI, 2.) Et₃N / 1.) CH₂Cl₂, RT, 2 h, 2.) CH₂Cl₂, 16 h

4: H₂ / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr

5: HOBT, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride (WSCDI) / tetrahydrofuran / 4.5 h / 0 - 20 °C

6: Dess-Martin periodinane reagent, CF₃COOH / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; potassium hydroxide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00082a005