(1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

Base Information

Chemical Name:(1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine
CAS No.:283598-06-1
Molecular Formula:C₅₂H₅₁N₃O₇
Molecular Weight:829.993
Hs Code.:

Synonyms:(1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

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Chemical Property of (1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

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Technology Process of (1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

There total 2 articles about (1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 283598-01-6
(1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

: 283598-06-1
(1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

Guidance literature:: (1'S,2'S,3'R)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine; With triethylamine; In methanol; water; at 20 ℃; for 12h;

4,4'-dimethoxytrityl chloride; With pyridine; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

: 132294-26-9
<1R-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

: 283598-06-1
(1'S,2'S,3'R)-1-{2',3'-bis[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}cytosine

Guidance literature:: Multi-step reaction with 2 steps

2.1: Et₃N / H₂O; methanol / 12 h / 20 °C

2.2: 86 percent / Py / 12 h / 20 °C

With triethylamine; In methanol; water; 2.1: Hydrolysis / 2.2: Substitution;
DOI:10.1016/S0040-4020(00)00162-9