Technology Process of (S,11E,19Z)-11,19-octacosadiene-1,3-diol 1-PMB ether
There total 13 articles about (S,11E,19Z)-11,19-octacosadiene-1,3-diol 1-PMB ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S,11E,19Z)-11,19-octacosadiene-1,3-diol;
With
potassium tert-butylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
Inert atmosphere;
p-methoxybenzyl chloride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 - 50 ℃;
for 5h;
Inert atmosphere;
DOI:10.1016/j.tet.2012.03.002
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol; potassium carbonate
2.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / -65 - -10 °C / Inert atmosphere
3.2: -65 - 20 °C / Inert atmosphere; Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethylene glycol dimethyl ether / 48 h / 10 - 140 °C / Inert atmosphere
4.2: Inert atmosphere; Cooling with ice
5.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
5.2: 5 h / 20 - 50 °C / Inert atmosphere
With
1H-imidazole; methanol; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; potassium carbonate;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.03.002
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane / -65 - -10 °C / Inert atmosphere
1.2: -65 - 20 °C / Inert atmosphere; Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethylene glycol dimethyl ether / 48 h / 10 - 140 °C / Inert atmosphere
2.2: Inert atmosphere; Cooling with ice
3.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
3.2: 5 h / 20 - 50 °C / Inert atmosphere
With
lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.03.002
