N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide

Base Information

Chemical Name:N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide
CAS No.:1060757-46-1
Molecular Formula:C₁₈H₁₅ClN₂O₃
Molecular Weight:342.782
Hs Code.:

Synonyms:N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide

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Chemical Property of N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide

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Technology Process of N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide

There total 1 articles about N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 95-85-2
2-hydroxy-5-chloro-aniline

: 534572-15-1
(+/-)-2-phenylspiro(cyclopropane-1',4-oxazoline)-5-carboxylic acid

: 1060757-46-1
N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide

Guidance literature:: (+/-)-2-phenylspiro(cyclopropane-1',4-oxazoline)-5-carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.25h; Inert atmosphere; Cooling with ice;

2-hydroxy-5-chloro-aniline; With 2,4,6-trimethyl-pyridine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/ejoc.200800333

Reference yield: 85.0%

: 1060757-46-1
N-(5-chloro-2-hydroxyphenyl)-5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-ene-7-carboxamide

: 1060757-58-5
5-chloro-2-(5-phenyl-6-oxa-4-azaspiro[2.4]hept-4-en-7-yl)benzoxazole

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1002/ejoc.200800333