2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

Base Information

Chemical Name:2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one
CAS No.:70764-68-0
Molecular Formula:C₂₆H₂₄ClNO₂
Molecular Weight:417.935
Hs Code.:

2-chloro-1'-phenethyl-spiro[dibenzo[<i>b</i>,<i>f</i>]oxepine-10,4'-piperidin]-11-one

Synonyms:2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

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Chemical Property of 2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

Chemical Property:

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Technology Process of 2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

There total 3 articles about 2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74403-81-9
2-chloro-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

: 622-24-2
2-phenylethyl chloride

: 70764-68-0
2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

Guidance literature:: With sodium hydrogencarbonate; potassium iodide; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 16h;
DOI:10.1021/jm00193a016

Reference yield:

: 74403-80-8
2-chloro-1'-methyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

: 70764-68-0
2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / CH₂Cl₂ / Heating

2: aq. HCl / 16 h / Heating

3: NaHCO₃, KI / dimethylformamide / 16 h / 70 - 80 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00193a016

Reference yield:

: 70764-47-5
4-[2-(4-chloro-phenoxy)-phenyl]-1-methyl-piperidine-4-carboxylic acid

: 70764-68-0
2-chloro-1'-phenethyl-spiro[dibenzo[b,f]oxepine-10,4'-piperidin]-11-one

Guidance literature:: Multi-step reaction with 4 steps

1: polyphosphoric acid / 1 h / 90 - 95 °C

2: K₂CO₃ / CH₂Cl₂ / Heating

3: aq. HCl / 16 h / Heating

4: NaHCO₃, KI / dimethylformamide / 16 h / 70 - 80 °C

With hydrogenchloride; PPA; sodium hydrogencarbonate; potassium carbonate; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00193a016