3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 871337-05-2
• Molecular Formula: C₁₆H₁₆BrClN₆
• Molecular Weight: 407.7
• Mol file: 871337-05-2.mol

Synonyms:3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

There total 1 articles about 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

4-(2-methyl-5-chlorophenyl)piperazine (76835-20-6) + 3-bromo-4-chloropyrazolo<3,4-d>pyrimidine (90914-41-3) → 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine (871337-05-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 85 ℃; for 0.5h;

Reference yield: 50.0%

3,4-dihydro-2H-pyran (110-87-2) + 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine (871337-05-2) → 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine (871338-04-4)

Guidance literature:

3,4-dihydro-2H-pyran; 3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine; With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 90 ℃; for 15h;

With sodium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield: 44.0%

3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine (871337-05-2) + (p-hydroxyphenyl)boronic acid (71597-85-8) → 4-{4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1H-pyrazolo[3,4-d]-pyrimidin-3-yl}phenol

Guidance literature:

With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 140 ℃; for 16h;

upstream raw materials:

4-(2-methyl-5-chlorophenyl)piperazine

3-bromo-4-chloropyrazolo<3,4-d>pyrimidine

Downstream raw materials:

3-bromo-4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

1,1-dimethylethyl (2E)-3-[4-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]prop-2-enoate