3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one

Base Information

• Chemical Name: 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one
• CAS No.: 871024-77-0
• Molecular Formula: C₂₇H₂₃ClNO₃P
• Molecular Weight: 475.911

Synonyms:3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one

Chemical Property of 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one

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Technology Process of 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one

There total 2 articles about 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-N-(4-chlorobenzylidene)-P,P-diphenylphosphinic amide (121197-50-0) + 1-phenyl-2-hydroxyethanone (582-24-1) → 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one + 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one (871024-77-0) + 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one

Guidance literature:

With (S,S)-trimethylsilyl-linked-binaphthol; bis(trimethylsilyl)amide yttrium(III); In tetrahydrofuran; at -20 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1246/bcsj.79.1906

Reference yield:

(E)-N-(4-chlorobenzylidene)-P,P-diphenylphosphinic amide (121197-50-0) + 1-phenyl-2-hydroxyethanone (582-24-1) → 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one + 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one (871024-77-0) + 3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one

Guidance literature:

With bis(trimethylsilyl)amide yttrium(III); (S,S)bis(2,2'-dihydroxy[1,1']binaphthalenyl-3-ylmethyl)ether; In tetrahydrofuran; at -20 ℃; for 60h; Further Variations:; Reagents; reaction times; Product distribution;

DOI:10.1021/ol052384+

Reference yield:

3-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-1-phenylpropan-1-one (871024-77-0) → (2R,3S)-3-Amino-3-(4-chloro-phenyl)-2-hydroxy-1-phenyl-propan-1-one

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃;

DOI:10.1021/ol052384+ DOI:10.1246/bcsj.79.1906

upstream raw materials:

(E)-N-(4-chlorobenzylidene)-P,P-diphenylphosphinic amide

1-phenyl-2-hydroxyethanone

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