tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate

Base Information

• Chemical Name: tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate
• CAS No.: 173943-89-0
• Molecular Formula: C₂₈H₃₆Cl₂N₂O₃
• Molecular Weight: 519.511

Synonyms:tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate

Chemical Property of tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate

Chemical Property:

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Technology Process of tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate

There total 6 articles about tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3H-spiro[2-benzofuran-1,4'-piperidine] (38309-60-3) + tert-Butyl N-methyl-N-[2-(3,4-dichlorophenyl)-4-methanesulphonyloxybutyl]carbamate (142001-76-1) → tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate (173943-89-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; Yield given;

DOI:10.1248/cpb.46.242

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate (173943-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / dioxane / 0.5 h / 60 °C

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: Et₃N / dimethylformamide / 70 °C

With triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.242

Reference yield:

N-[2-(S)-(3,4-dichlorophenyl)-4-hydroxybutyl]-N-methylamine (152298-54-9,736905-09-2,786611-77-6) → tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate (173943-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / dioxane / 0.5 h / 60 °C

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: Et₃N / dimethylformamide / 70 °C

With triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.242

upstream raw materials:

3H-spiro[2-benzofuran-1,4'-piperidine]

tert-Butyl N-methyl-N-[2-(3,4-dichlorophenyl)-4-methanesulphonyloxybutyl]carbamate

di-tert-butyl dicarbonate

N-[2-(S)-(3,4-dichlorophenyl)-4-hydroxybutyl]-N-methylamine

Downstream raw materials:

(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

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