1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)-
CAS No.:115909-95-0
Molecular Formula:C₁₆H₂₀N₂O₂
Molecular Weight:272.347
Hs Code.:
DSSTox Substance ID:DTXSID001148809

Synonyms:DTXSID001148809;1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)-;115909-95-0

Suppliers and Price of 1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)-

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:272.152477885
Heavy Atom Count:20
Complexity:355

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(CN(C1)C(=O)OCC2=CC=CC=C2)CCC#N
Isomeric SMILES:C1C[C@@H](CN(C1)C(=O)OCC2=CC=CC=C2)CCC#N

Technology Process of 1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)-

There total 5 articles about 1-Piperidinecarboxylic acid, 3-(2-cyanoethyl)-, phenylmethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 143-33-9,25596-52-5
sodium cyanide

: 115909-94-9
(+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-ethhyl p-Toluolsulfonat

: 115909-95-0
(+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-propionitril

Guidance literature:: In dimethyl sulfoxide; at 65 ℃; for 2.5h;
DOI:10.1002/hlca.19870700802

Reference yield:

: 73579-06-3,115909-92-7
3-(2-hydroxyethyl)piperidine

: 115909-95-0
(+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-propionitril

Guidance literature:: Multi-step reaction with 4 steps

2: 80 percent / 4N NaOH / tetrahydrofuran; H₂O / 1.5 h / 0 °C

3: 96 percent / pyridine / 2 h / 0 °C

4: 94 percent / dimethylsulfoxide / 2.5 h / 65 °C

With pyridine; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1002/hlca.19870700802

Reference yield:

: 74494-52-3
3-Piperidinylacetic Acid

: 115909-95-0
(+)-(R)-1-(Benzyloxycarbonyl)piperidin-3-propionitril

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / LiAlH / tetrahydrofuran / 4 h / Heating

3: 80 percent / 4N NaOH / tetrahydrofuran; H₂O / 1.5 h / 0 °C

4: 96 percent / pyridine / 2 h / 0 °C

5: 94 percent / dimethylsulfoxide / 2.5 h / 65 °C

With pyridine; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1002/hlca.19870700802