2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid

Base Information

• Chemical Name: 2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid
• CAS No.: 237381-57-6
• Molecular Formula: C₁₇H₁₅N₃O₃S₃
• Molecular Weight: 405.522

Synonyms:2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid

Chemical Property of 2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid

Chemical Property:

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Technology Process of 2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid

There total 1 articles about 2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-{3-[2-(5-{[(tert-butoxy)carbonylamino]iminomethyl}-2-methylthio-3-thienyl)-1,3-thiazol-4-yl]phenoxy}acetate (237384-52-0) → 2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid (237381-57-6)

Guidance literature:

In dichloromethane; water; trifluoroacetic acid;

Reference yield: 45.0%

2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid (237381-57-6) + O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) HATU → (D,L)-ethyl 1-(2-{3-[2-(5-amidino-2-methylthio-3-thienyl)-1,3-thiazol-4-yl]phenoxy}acetyl)piperidine-3-carboxylate trifluoroacetate (237382-04-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield: 42.0%

2-{3-[2-(5-amidino-2-methylthio-thien-3-yl)-1,3-thiazol-4-yl]phenoxy}acetic acid (237381-57-6) + O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) HATU → ethyl 1-(2-{3-[2-(5-amidino-2-methylthio-3-thienyl)-1,3-thiazol-4-yl]phenoxy}acetyl)piperidine-4-carboxylate trifluoroacetate (237382-08-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 2-{3-[2-(5-{[(tert-butoxy)carbonylamino]iminomethyl}-2-methylthio-3-thienyl)-1,3-thiazol-4-yl]phenoxy}acetate

Downstream raw materials:

5-methylthio-4-[4-(3-{2-oxo-2-[4-benzylpiperidyl]ethoxy}phenyl)(1,3-thiazol-2-yl)]thiophene-2-carboxamidine trifluoroacetate

4-(4-{3-[2-(2-azabicyclo[4.4.0]dec-2-yl)-2-oxoethoxy]phenyl}(1,3-thiazol-2-yl))-5-methylthiothiophene-2-carboxamidine trifluoroacetate

(D,L)-4-(4-{3-[2-(3-methylpiperidyl)-2-oxoethoxy]phenyl}(1,3-thiazol-2-yl))-5-methylthiothiophene-2-carboxamidine trifluoroacetate

4-(4-{3-[2-(4-methylpiperidyl)-2-oxoethoxy]phenyl}(1,3-thiazol-2-yl))-5-methylthiothiophene-2-carboxamidine trifluoroacetate

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