1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

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Chemical Name:1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate
CAS No.:787635-22-7
Molecular Formula:C₂₅H₃₅NO₅S
Molecular Weight:461.623
Hs Code.:

Synonyms:1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

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Chemical Property of 1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

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Technology Process of 1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

There total 3 articles about 1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 127392-81-8
1-((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-3-phenylpropan-1-one

: 787635-22-7
1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

Guidance literature:: 1-((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)-3-phenylpropan-1-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

bromoacetic acid tert-butyl ester; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -78 ℃; for 16h;

In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1002/hlca.200490174

Reference yield:

: 645-45-4
hydrocinnamic acid chloride

: 787635-22-7
1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / toluene; tetrahydrofuran / 1 h / 20 °C

1.2: 91 percent / tetrahydrofuran; toluene / 16 h

2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C

With sodium hexamethyldisilazane; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1081/SCC-200025625

Reference yield:

: 94594-90-8,124224-04-0
(2R)-bornane-10,2-sultam

: 787635-22-7
1,1-dimethylethyl (3S)-4-[(3aS,6R,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxo-3-(phenylmethyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / toluene; tetrahydrofuran / 1 h / 20 °C

1.2: 91 percent / tetrahydrofuran; toluene / 16 h

2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 92 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 h / -78 - 25 °C

With sodium hexamethyldisilazane; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1081/SCC-200025625