2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Base Information

• Chemical Name: 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide
• CAS No.: 1400650-24-9
• Molecular Formula: C₃₃H₄₃FN₂O₃S
• Molecular Weight: 566.78
• Mol file: 1400650-24-9.mol

Synonyms:2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Chemical Property of 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

There total 14 articles about 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C42H53FN2O5S → 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (1400650-24-9)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 0 - 20 ℃; for 21h;

DOI:10.1248/cpb.c15-00803

Reference yield:

1-bromo-hexane (111-25-1) → 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (1400650-24-9)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

4: pyridine / chloroform / 13 h / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 15 h / 20 °C

6: potassium hydroxide / water; ethanol / 15 h / 20 °C

7: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

8: trifluoroacetic acid / chloroform / 21 h / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c15-00803

Reference yield:

7-bromo-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonyl chloride (1400653-03-3) → 2-[2-(4-tert-butylphenyl)ethyl]-N-[2-fluoro-4-(hexyloxy)phenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (1400650-24-9)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / chloroform / 13 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 15 h / 20 °C

3: potassium hydroxide / water; ethanol / 15 h / 20 °C

4: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

5: trifluoroacetic acid / chloroform / 21 h / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; potassium hydroxide; In methanol; ethanol; chloroform; water; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1248/cpb.c15-00803

upstream raw materials:

1-bromo-hexane

7-bromo-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonyl chloride

7-bromo-1,2,3,4-tetrahydroisoquinoline

1-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one

Refernces

• 1、 -. "NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND". Paragraph 0645. . Retrieved 2014/02/15.