sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

Base Information

Chemical Name:sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate
CAS No.:603122-44-7
Molecular Formula:C₂₅H₂₃ClNO₃*Na
Molecular Weight:443.905
Hs Code.:

Synonyms:sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

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Chemical Property of sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

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Technology Process of sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

There total 13 articles about sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

: 603122-42-5
methyl 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

: 603122-44-7
sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

Guidance literature:: With sodium hydroxide; In water; for 3h; Reflux;
DOI:10.1021/jm800222k

Reference yield:

: 603122-35-6
methyl 4-((7S)-7-{[(benzyloxy)carbonyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

: 2788-86-5,53649-47-1,97466-49-4,21019-51-2
(R)-2-(4-chlorophenyl)oxirane

: 603122-44-7
sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 18 h / Reflux

2: sodium hydroxide / water / 3 h / Reflux

With sodium hydroxide; In ethanol; water;
DOI:10.1021/jm800222k

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 603122-44-7
sodium 4-((7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: AD-mixβ; water / tert-butyl alcohol / 4 h / Cooling with ice

2: Trimethyl orthoacetate; chloro-trimethyl-silane / dichloromethane / 1 h / Cooling with ice

3: ethanol / 18 h / Reflux

4: sodium hydroxide / water / 3 h / Reflux

With Trimethyl orthoacetate; sodium hydroxide; chloro-trimethyl-silane; AD-mixβ; water; In ethanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm800222k