N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide

Base Information

• Chemical Name: N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide
• CAS No.: 1381846-08-7
• Molecular Formula: C₁₆H₁₉ClN₄O₂
• Molecular Weight: 334.805
• Mol file: 1381846-08-7.mol

Synonyms:N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide

Chemical Property of N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide

There total 2 articles about N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-chloro-5-(isobutyramidomethyl)-4-methylbenzoic acid (1381846-29-2) + 2-aminoimidazolesulfate (42383-61-9) → N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide (1381846-08-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

Reference yield:

N-(hydroxymethyl)-2-methylpropanamide (20605-08-7) + 2-chloro-4-methylbenzoic acid (7697-25-8) → N-(1H-imidazol-2-yl)-2-chloro-4-methyl-5-(isobutyramidomethyl)benzamide (1381846-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 60 °C

2.2: 60 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.5b01249

upstream raw materials:

2-chloro-5-(isobutyramidomethyl)-4-methylbenzoic acid

2-aminoimidazolesulfate

N-(hydroxymethyl)-2-methylpropanamide

2-chloro-4-methylbenzoic acid