(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

Chemical Name:(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
CAS No.:841226-17-3
Molecular Formula:C₄₁H₆₈O₇Si
Molecular Weight:701.072
Hs Code.:

(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Synonyms:(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Suppliers and Price of (4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 4 articles about (4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76438-34-1
(S)-2-(tetrahydropyranyloxy)propanal

: 837428-43-0
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (4R,10R)-10-hydroxy-12-(trimethylsilyl)-4-[2-(trimethylsilyl)ethoxy]dodec-11-ynoate

: 841226-17-3
(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: (S)-2-(tetrahydropyranyloxy)propanal; (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (4R,10R)-10-hydroxy-12-(trimethylsilyl)-4-[2-(trimethylsilyl)ethoxy]dodec-11-ynoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

With potassium carbonate; In methanol; at 20 ℃; for 12h;
DOI:10.1021/ol0479242

Reference yield:

: (4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-12-trimethylsilanyl-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

: 841226-17-3
(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: With potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃; for 12h;
DOI:10.1021/jo052233k

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: 841226-17-3
(4R,10R)-10-Hydroxy-2-[(S)-1-hydroxy-2-(tetrahydro-pyran-2-yloxy)-propyl]-4-(2-trimethylsilanyl-ethoxy)-dodec-11-ynoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Zn(OTf)2; (1R,2S)-N-methylephedrine; Et₃N / toluene / 20 h / 60 °C

2: LDA / tetrahydrofuran / 1 h / -78 °C

3: K₂CO₃ / tetrahydrofuran; methanol / 12 h / 20 °C

With (-)-N-methylephedrine; zinc trifluoromethanesulfonate; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo052233k