1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea

Base Information

Chemical Name:1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea
CAS No.:1218763-17-7
Molecular Formula:C₂₁H₁₉F₇N₄O₂
Molecular Weight:492.396
Hs Code.:

Synonyms:1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea

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Chemical Property of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea

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Technology Process of 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea

There total 2 articles about 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1218761-04-6
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

: 1218763-17-7
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea

Guidance literature:: With acetic acid; sodium nitrite; In water; at 10 - 35 ℃; for 72h;

Reference yield:

: 1218761-03-5
tert-butyl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

: 1218763-17-7
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)-1-nitrosopyrrolidin-3-yl]-1,3-dimethylurea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / isopropyl alcohol / 2.5 h / 10 - 45 °C

2: sodium nitrite; acetic acid / water / 72 h / 10 - 35 °C

With hydrogenchloride; acetic acid; sodium nitrite; In water; isopropyl alcohol;