n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate

Base Information

• Chemical Name: n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate
• CAS No.: 73035-74-2
• Molecular Formula: C₃₆H₄₉NO₃S
• Molecular Weight: 575.856
• Mol file: 73035-74-2.mol

Synonyms:n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate

Chemical Property of n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate

There total 2 articles about n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

tosylate de n-hexadecyle (6068-28-6,53012-52-5) + 6-<2-(4'-Phenylthio)phenethyl>-2-pyridone-3-carboxylic acid (72918-12-8) → n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate (73035-74-2)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 60 ℃; for 24h;

DOI:10.1021/jo01296a002

Reference yield:

2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid (72918-11-7) → n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate (73035-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Iodotrimethylsilane / CHCl₃ / 18 h / Ambient temperature

2: 60 percent / hexamethylphosphoric acid triamide / 24 h / 60 °C

With trimethylsilyl iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform;

DOI:10.1021/jo01296a002

Reference yield: 32.0%

n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-2-pyridone-3-carboxylate (73035-74-2) + dimethyl sulfate (77-78-1) → n-Hexadecyl 2-methoxy-6-<2-(4'-phenylthio)phenethyl>-2-pyridine-3-carboxylate (72918-13-9) + n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-1-methyl-2-pyridone-3-carboxylate (72918-14-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jo01296a002

upstream raw materials:

tosylate de n-hexadecyle

6-<2-(4'-Phenylthio)phenethyl>-2-pyridone-3-carboxylic acid

2-Methoxy-6-<2-(4'-phenylthio)phenethyl>pyridine-3-carboxylic acid

Downstream raw materials:

n-Hexadecyl 2-methoxy-6-<2-(4'-phenylthio)phenethyl>-2-pyridine-3-carboxylate

n-Hexadecyl 6-<2-(4'-phenylthio)phenethyl>-1-methyl-2-pyridone-3-carboxylate