(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

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Chemical Name:(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate
CAS No.:1383742-83-3
Molecular Formula:C₂₅H₂₂ClF₂N₇O₃
Molecular Weight:541.945
Hs Code.:

(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

Synonyms:(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

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Chemical Property of (R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

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Technology Process of (R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

There total 3 articles about (R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383742-67-3
t-butyl (R)-(6-(5-((tert-butoxycarbonyl)amino)-2-fluorophenyl)-3-iodo-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl)carbamate

: 1383742-83-3
(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 160 °C / microwave irradiation

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: dichloromethane / 0.5 h / 20 °C

4: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 24 h / 0 - 20 °C

With trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1383742-74-2
(R)-tert-butyl {3-[8-amino-3-cyano-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-6-yl]-4-fluorophenyl}carbamate

: 1383742-83-3
(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2: dichloromethane / 0.5 h / 20 °C

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 24 h / 0 - 20 °C

With trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; dichloromethane;

Reference yield:

: 1383742-75-3
(R)-8-amino-6-(5-amino-2-fluorophenyl)-2-chloro-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazine-3-carbonitrile

: 1383742-83-3
(R)-tert-butyl [2-chloro-3-cyano-6-(2-fluoro-5-{[(5-fluoropyridin-2-yl)carbonyl]amino}phenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0.5 h / 20 °C

2: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 24 h / 0 - 20 °C

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; dichloromethane;