N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

Base Information

Chemical Name:N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide
CAS No.:97995-49-8
Molecular Formula:C₂₃H₃₄N₂O₂
Molecular Weight:370.535
Hs Code.:

Synonyms:N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

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Chemical Property of N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

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Technology Process of N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

There total 8 articles about N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

: 97920-05-3
N-Benzyl-N-methyl-2-[(1S,6R)-6-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohex-3-enyl]-acetamide

: 97995-49-8
N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1021/jo00221a022

Reference yield:

: 439919-46-7
cis-1,6-dihydroxymethyl-3-cyclohexene

: 97995-49-8
N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 72.1 percent / pyridine / 24 h / Ambient temperature

2: aq. KOH / ethanol / 96 h / Heating

3: 63.6 percent / dicyclohexylcarbodiimide, pyridine / 144 h / Ambient temperature

4: 51.2 percent / tetrahydrofuran / 3 h / -78 °C

5: 50 percent / tetrahydrofuran / 0.05 h / Ambient temperature

6: 74.2 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

With pyridine; potassium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jo00221a022

Reference yield:

: 25886-62-8
cis-2,2'-(cyclohex-4-ene-1,2-diyl)diacetic acid

: 97995-49-8
N-Benzyl-N-methyl-2-[(1S,2R)-2-(2-oxo-2-piperidin-1-yl-ethyl)-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 63.6 percent / dicyclohexylcarbodiimide, pyridine / 144 h / Ambient temperature

2: 51.2 percent / tetrahydrofuran / 3 h / -78 °C

3: 50 percent / tetrahydrofuran / 0.05 h / Ambient temperature

4: 74.2 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

With pyridine; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jo00221a022