12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one

Base Information

• Chemical Name: 12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one
• CAS No.: 1261967-78-5
• Molecular Formula: C₂₀H₁₉ClN₂O
• Molecular Weight: 338.837

Synonyms:12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one

Chemical Property of 12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one

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Technology Process of 12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one

There total 1 articles about 12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(E)-1-cyclooctenylpyrrolidine (942-81-4) + 2-<(3-chlorophenyl)amino>-3-pyridinecarbonyl chloride (110546-46-8) → 12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one (1261967-78-5)

Guidance literature:

With triethylamine; In toluene; at -10 - 80 ℃; for 18.67h;

DOI:10.1016/j.tet.2010.10.043

Reference yield: 37.0%

12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one (1261967-78-5) → 14-(3-chlorophenyl)-7,8,9,10,11,12-hexahydropyrido[2,3-b][1]azacyclododecene-5,6,13-(14H)-trione (1261967-83-2)

Guidance literature:

With sodium periodate; rhodium(III) chloride hydrate; sulfuric acid; In water; ethyl acetate; acetonitrile; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2010.10.043

Reference yield: 24.0%

12-(3-chlorophenyl)-6,7,8,9,10,11-hexahydrocycloocta[b][1,8]naphthyridin-5(12H)-one (1261967-78-5) → 14-(3-chlorophenyl)-7,8,9,10,11,12-hexahydropyrido[2,3-b][1]azacyclododecene-5,6,13-(14H)-trione (1261967-83-2) + 6-(1-(3-chlorophenyl)-3-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl)hexanal (1261967-86-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 60h;

DOI:10.1016/j.tet.2010.10.043

upstream raw materials:

(E)-1-cyclooctenylpyrrolidine

2-<(3-chlorophenyl)amino>-3-pyridinecarbonyl chloride

Downstream raw materials:

14-(3-chlorophenyl)-7,8,9,10,11,12-hexahydropyrido[2,3-b][1]azacyclododecene-5,6,13-(14H)-trione

6-(1-(3-chlorophenyl)-3-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl)hexanal

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