N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

Base Information

Chemical Name:N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide
CAS No.:1446019-89-1
Molecular Formula:C₁₈H₂₁BrN₄O
Molecular Weight:389.295
Hs Code.:

Synonyms:N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

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Chemical Property of N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

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Technology Process of N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

There total 6 articles about N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446021-11-9
N-(1-(4-(azetidin-3-yl)phenyl)propan-2-yl)acetamide

: 32779-36-5
5-Bromo-2-chloropyrimidine

: 1446019-89-1
N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 35 ℃;

Reference yield:

: 1197684-85-7,1395463-00-9
N-[2-(4-bromophenyl)-1-methyl-ethyl]acetamide

: 1446019-89-1
N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; N,N-dimethylethylenediamine; sodium iodide / 1,4-dioxane / 70 h / 120 °C

2.1: chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc / tetrahydrofuran / 16 h / 20 - 70 °C / Inert atmosphere

2.2: 1.5 h / 70 °C

3.1: hydrogenchloride / methanol / 8 h / 35 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 35 °C

With hydrogenchloride; copper(l) iodide; chloro-trimethyl-silane; ethylene dibromide; N,N-dimethylethylenediamine; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; 2.2: |Negishi Coupling;

Reference yield:

: 13235-83-1
(±)-1-(4-bromophenyl)propan-2-amine

: 1446019-89-1
N-(1-(4-(1-(5-bromopyrimidin-2-yl)azetidin-3-yl)phenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 20 °C

2.1: copper(l) iodide; N,N-dimethylethylenediamine; sodium iodide / 1,4-dioxane / 70 h / 120 °C

3.1: chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc / tetrahydrofuran / 16 h / 20 - 70 °C / Inert atmosphere

3.2: 1.5 h / 70 °C

4.1: hydrogenchloride / methanol / 8 h / 35 °C

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 35 °C

With hydrogenchloride; copper(l) iodide; chloro-trimethyl-silane; acetic acid; ethylene dibromide; N,N-dimethylethylenediamine; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium chloride; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; dimethyl sulfoxide; 3.2: |Negishi Coupling;