2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine

Base Information

• Chemical Name: 2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine
• CAS No.: 852030-66-1
• Molecular Formula: C₁₉H₂₆N₆O₄S
• Molecular Weight: 434.519

Synonyms:2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine

Chemical Property of 2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine

Chemical Property:

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Technology Process of 2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine

There total 2 articles about 2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-amino-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine (852030-64-9) + p-toluenesulfonic-acid-(2-isopropoxyethyl)-ester (51218-98-5) → 2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine (852030-66-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 5h;

DOI:10.1021/jm049012b

Reference yield:

2,6-diamino-9H-purine-8-thiol (462066-71-3) → 2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine (852030-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / CuI; NaOt-Bu / ethane-1,2-diol / 15 h / 130 °C

2: 49 percent / Cs₂CO₃ / dimethylformamide / 5 h / 80 °C

With copper(l) iodide; caesium carbonate; sodium t-butanolate; In ethylene glycol; N,N-dimethyl-formamide;

DOI:10.1021/jm049012b

Reference yield: 71.0%

2-amino-9-(2-isopropoxy-ethyl)-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine (852030-66-1) → 2-amino-9-(2-isopropoxy-ethyl)-8-(2-chloro-3,4,5-trimethoxy-phenylsulfanyl)adenine (852030-68-3)

Guidance literature:

With hydrogenchloride; tert.-butylhydroperoxide; In methanol; at 80 ℃;

DOI:10.1021/jm049012b

upstream raw materials:

2-amino-8-(3,4,5-trimethoxy-phenylsulfanyl)adenine

p-toluenesulfonic-acid-(2-isopropoxyethyl)-ester

2,6-diamino-9H-purine-8-thiol

Downstream raw materials:

2-amino-9-(2-isopropoxy-ethyl)-8-(2-chloro-3,4,5-trimethoxy-phenylsulfanyl)adenine

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