2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

Base Information

Chemical Name:2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide
CAS No.:1427407-80-4
Molecular Formula:C₂₁H₁₆F₃NO₂
Molecular Weight:371.359
Hs Code.:

Synonyms:2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

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Chemical Property of 2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

Chemical Property:

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Technology Process of 2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

There total 11 articles about 2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427407-79-1
3-amino-4-fluoro-2,5-dimethylphenol

: 1427407-80-4
2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 1227210-35-6
1-bromo-4-fluoro-2-methyl-3-nitro-benzene

: 1427407-80-4
2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: iron; ammonium chloride / ethanol / 3 h / Reflux

2.1: dmap; triethylamine / N,N-dimethyl-formamide

3.1: sec.-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran / 2 h / -65 °C

3.2: 0.5 h / -65 - -10 °C

4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

5.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 0 - 10 °C

6.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

7.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 0 - 20 °C

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; dihydrogen peroxide; sec.-butyllithium; potassium acetate; iron; sodium hydrogencarbonate; ammonium chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3013-27-2
1-fluoro-3-methyl-2-nitro-benzene

: 1427407-80-4
2-fluoro-N-(2-fluoro-5-hydroxy-3,6-dimethyl-phenyl)-5-(3-fluorophenyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; N-Bromosuccinimide / 2 h / 20 °C

2.1: iron; ammonium chloride / ethanol / 3 h / Reflux

3.1: dmap; triethylamine / N,N-dimethyl-formamide

4.1: sec.-butyllithium; 2,2,6,6-tetramethyl-piperidine / tetrahydrofuran / 2 h / -65 °C

4.2: 0.5 h / -65 - -10 °C

5.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

6.1: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 0 - 10 °C

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

8.1: sodium hydrogencarbonate / tetrahydrofuran / 0.5 h / 0 - 20 °C

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sulfuric acid; water; dihydrogen peroxide; sec.-butyllithium; potassium acetate; iron; sodium hydrogencarbonate; ammonium chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;