5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

Base Information

Chemical Name:5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine
CAS No.:588718-66-5
Molecular Formula:C₃₃H₅₈N₃O₉PSi₂
Molecular Weight:727.983
Hs Code.:

Synonyms:5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

Chemical Property:

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Technology Process of 5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

There total 3 articles about 5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87418-87-9,69504-12-7
2',3'-bis-O-(tert-butyldimethylsilyl)uridine

: 588718-66-5
5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

Guidance literature:: Multi-step reaction with 3 steps

1: EDC; DMSO; pyridine / TFA / benzene

2: benzene / 4 h / Heating

3: 349 mg / LHMDS / tetrahydrofuran / 0 - 20 °C

With pyridine; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium hexamethyldisilazane; trifluoroacetic acid; In tetrahydrofuran; benzene; 1: Moffatt oxidation;
DOI:10.1021/jo030050x

Reference yield:

: 762-04-9
phosphonic acid diethyl ester

: 1-((2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-{[(E)-4-methoxy-benzylimino]-methyl}-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: [[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-(4-methoxy-benzylamino)-methyl]-phosphonic acid diethyl ester

: 588718-66-5
5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

: 588718-64-3
5'S-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jo030050x

Reference yield:

: 161867-43-2
(2S,3R,4R,5R)-3,4-bis(tert-butyldimethylsilanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-carbaldehyde

: 588718-66-5
5'R-(p-methoxybenzyl)amino-5'-diethylphosphonyl-2',3'-di-O-t-butyldimethylsilyl uridine

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 4 h / Heating

2: 349 mg / LHMDS / tetrahydrofuran / 0 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; benzene;
DOI:10.1021/jo030050x