benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate

Base Information

• Chemical Name: benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate
• CAS No.: 1244784-72-2
• Molecular Formula: C₄₁H₅₈O₅Si
• Molecular Weight: 658.994
• Mol file: 1244784-72-2.mol

Synonyms:benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate

Chemical Property of benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate

There total 2 articles about benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

diphenylacetic anhydride (1760-46-9) + benzyl 14-(tert-butyldimethylsiloxy)-2-hydroxytetradecanoate (1244784-67-5) → benzyl (S)-14-(tert-butyldimethylsiloxy)-2-hydroxytetradecanoate (1244784-71-1) + benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate (1244784-72-2)

Guidance literature:

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; at 20 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.08.018

Reference yield: 48.0%

2,2-diphenylacetic acid (117-34-0) + benzyl 14-(tert-butyldimethylsiloxy)-2-hydroxytetradecanoate (1244784-67-5) → benzyl (S)-14-(tert-butyldimethylsiloxy)-2-hydroxytetradecanoate (1244784-71-1) + benzyl (R)-14-(tert-butyldimethylsiloxy)-2-(diphenylacetyloxy)tetradecanoate (1244784-72-2)

Guidance literature:

With 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; In diethyl ether; at 20 ℃; for 12h; Product distribution / selectivity;

upstream raw materials:

diphenylacetic anhydride

benzyl 14-(tert-butyldimethylsiloxy)-2-hydroxytetradecanoate

2,2-diphenylacetic acid