ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate

Base Information

• Chemical Name: ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate
• CAS No.: 131772-89-9
• Molecular Formula: C₁₉H₁₆ClN₃O₄
• Molecular Weight: 385.807
• Mol file: 131772-89-9.mol

Synonyms:ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate

Chemical Property of ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate

There total 1 articles about ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 2-(4-hydroxyphenoxy)propanoate (65343-67-1) + 2,6-dichloro-3-cyanoimidazo[1,2-a]pyridine (131773-31-4) → ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate (131772-89-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; paraffin; 1.) room temperature, 20 min, 2.) 130 - 135 deg C, 6 h;

Reference yield: 78.0%

ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate (131772-89-9) → 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionic acid (131772-90-2)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; for 2.5h; Ambient temperature;

Reference yield:

ethyl 2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionate (131772-89-9) → 2-[4-(6-Chloro-3-cyano-imidazo[1,2-a]pyridin-2-yloxy)-phenoxy]-propionic acid isopropyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 8percent NaOH / H₂O; acetonitrile / 2.5 h / Ambient temperature

2: N,N'-carbodiimidazole / CH₂Cl₂ / 1 h / Ambient temperature

With sodium hydroxide; 1,1'-carbonyldiimidazole; In dichloromethane; water; acetonitrile;

upstream raw materials:

ethyl 2-(4-hydroxyphenoxy)propanoate

2,6-dichloro-3-cyanoimidazo[1,2-a]pyridine

Downstream raw materials:

2-<4-(6-chloro-3-cyano-2-imidazo<1,2-a>pyridinyloxy)phenoxy>propionic acid