2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

Base Information

Chemical Name:2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate
CAS No.:680199-27-3
Molecular Formula:C₁₆H₂₄N₄O₁₃S₂
Molecular Weight:544.518
Hs Code.:

Synonyms:2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

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Chemical Property of 2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

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Technology Process of 2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

There total 4 articles about 2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: methanesulfonic acid 2-[(5-chlorocarbonyl-2,4-dinitro-phenyl)-(2-methanesulfonyloxy-ethyl)-amino]-ethyl ester

: 616-30-8,13552-31-3,98923-21-8
3-Amino-1,2-propanediol

: methanesulfonic acid 2-{(2-chloro-ethyl)-[5-(2,3-dihydroxy-propylcarbamoyl)-2,4-dinitro-phenyl]-amino}-ethyl ester

: 680199-27-3
2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

Guidance literature:: for 0.166667h;
DOI:10.1021/jm061062o

Reference yield:

: 680199-23-9
methyl 5-(bis{2-[(methylsulfonyl)oxy]ethyl}amino)-2,4-dinitrobenzoate

: 680199-27-3
2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / dioxane; methanol / 0.25 h / 20 °C

2: SOCl₂; DMF / 1 h / Heating

3: 71 percent / 0.17 h

With potassium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; methanol;
DOI:10.1021/jm061062o

Reference yield:

: 150272-09-6
methyl 5--2,4-dinitrobenzoate

: 680199-27-3
2-(5-{[(2,3-dihydroxypropyl) amino] carbonyl}{2-[(methylsulfonyl)oxy]ethyl}-2,4-dinitroanilino)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Et₃N; aq. KHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: KOH / dioxane; methanol / 0.25 h / 20 °C

3: SOCl₂; DMF / 1 h / Heating

4: 71 percent / 0.17 h

With potassium hydroxide; thionyl chloride; potassium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm061062o