(+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:(+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate
CAS No.:253882-01-8
Molecular Formula:C₂₀H₂₇NO₄
Molecular Weight:345.439
Hs Code.:

Synonyms:(+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

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Chemical Property of (+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

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Technology Process of (+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

There total 10 articles about (+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 205068-11-7
4-oxo-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

: 253882-01-8
(+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With Alpine borane; ethanolamine; acetaldehyde; In neat (no solvent); Ambient temperature;
DOI:10.1016/S0040-4039(98)00085-9

Reference yield:

: 205068-11-7
4-oxo-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

: 253882-01-8
(+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

: (-)-(R)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With (-)-(S)-alpine-borane; In tetrahydrofuran; at 0 - 20 ℃; Title compound not separated from byproducts;
DOI:10.1021/jo991095u

Reference yield:

: 536-74-3
phenylacetylene

: 253882-01-8
(+)-(S)-4-hydroxy-6-phenyl-5-hexynyl 2,2,4,4-tetramethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / n-BuLi / tetrahydrofuran / -78 - -18 °C

2: 69 percent / PCC; NaOAc / CH₂Cl₂ / 0 - 20 °C

3: (R)-Alpine-borane / tetrahydrofuran / 0 - 20 °C

With n-butyllithium; B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; sodium acetate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 1: Addition / 2: Oxidation / 3: Reduction;
DOI:10.1021/jo991095u