6-amino>indole

Base Information

Chemical Name:6-amino>indole
CAS No.:104447-62-3
Molecular Formula:C₁₄H₁₆N₂O₂
Molecular Weight:244.293
Hs Code.:

6-<N-<(cyclopentyloxy)carbonyl>amino>indole

Synonyms:6-amino>indole

Suppliers and Price of 6-amino>indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino>indole

Chemical Property:

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Technology Process of 6-amino>indole

There total 1 articles about 6-amino>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 5318-27-4
6-amino-1H-indole

: 50715-28-1
cyclopentyl chloroformate

: 104447-62-3
6-amino>indole

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm00091a010

Reference yield:

: 104447-62-3
6-amino>indole

: 104447-61-2
methyl 4-<<3-acetyl-6-amino>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) POCl₃, 2.) aq. NaOH / 1.) from 0 deg C to RT, 2.) 60 deg C, 30 min, 3.) reflux, 10 min

2: 78 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

With sodium hydroxide; potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010

Reference yield:

: 104447-62-3
6-amino>indole

: 104448-68-2
[3-Acetyl-1-(4-benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indol-6-yl]-carbamic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) POCl₃, 2.) aq. NaOH / 1.) from 0 deg C to RT, 2.) 60 deg C, 30 min, 3.) reflux, 10 min

2: 78 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

3: 99 percent / aq. LiOH / methanol; tetrahydrofuran

4: 64 percent / Me₂N(CH₂)3N=C=NEt*HCl, DMAP / CH₂Cl₂

With dmap; lithium hydroxide; sodium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010