Technology Process of [4-(N,N-dimethylamino)phenyl]diphenylacetonitrile
There total 4 articles about [4-(N,N-dimethylamino)phenyl]diphenylacetonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; caesium carbonate;
In
1,4-dioxane;
at 105 ℃;
for 20h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/ol503213z
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium carbonate / 1,4-dioxane; water / 12 h / 60 °C / Inert atmosphere; Sealed tube
2: potassium phosphate; tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere; Sealed tube
3: tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; caesium carbonate / 1,4-dioxane / 20 h / 105 °C / Inert atmosphere; Sealed tube
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; sodium carbonate; caesium carbonate;
In
1,4-dioxane; water;
DOI:10.1021/ol503213z
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dicyclohexyl-({2-[2-(dicyclohexylphosphanyl)phenyl]-phenyl})-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere; Sealed tube
2: tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; caesium carbonate / 1,4-dioxane / 20 h / 105 °C / Inert atmosphere; Sealed tube
With
potassium phosphate; tri-tert-butylphosphonium tetrafluoroborate; dicyclohexyl-({2-[2-(dicyclohexylphosphanyl)phenyl]-phenyl})-phosphane; palladium diacetate; caesium carbonate;
In
1,4-dioxane;
DOI:10.1021/ol503213z
