3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

Base Information

Chemical Name:3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione
CAS No.:1639426-14-4
Molecular Formula:C₂₄H₂₂N₂O₅
Molecular Weight:418.449
Hs Code.:

Synonyms:3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

Suppliers and Price of 3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

There total 9 articles about 3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4315-09-7
4-nitroisophthalic acid

: 1639426-14-4
3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / Reflux

2: hydrogen; palladium 10% on activated carbon

3: pyridine / 100 °C

4: caesium carbonate / N,N-dimethyl-formamide / 20 °C

5: sulfuric acid; acetic acid / water / 100 °C

6: thionyl chloride / tetrahydrofuran / Reflux

7: triethylamine / chloroform / 0 °C

8: triethylamine; 2-hydroxy-2-methylpropanenitrile / dichloromethane / 20 °C

With pyridine; thionyl chloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; caesium carbonate; acetic acid; triethylamine; 2-hydroxy-2-methylpropanenitrile; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 8: |Fries Phenol Ester Rearrangement;
DOI:10.1021/jf5048089

Reference yield:

: 3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-enylcarboxy)-1-methylquinazoline-2,4(1H,3H)-dione

: 1639426-14-4
3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

Guidance literature:: With triethylamine; 2-hydroxy-2-methylpropanenitrile; In dichloromethane; at 20 ℃;
DOI:10.1021/jf5048089

Reference yield:

: C₁₈H₁₆N₂O₄

: 1639426-14-4
3-(2,6-dimethylphenyl)-6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-1-methylquinazoline-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / tetrahydrofuran / Reflux

2: triethylamine / chloroform / 0 °C

3: triethylamine; 2-hydroxy-2-methylpropanenitrile / dichloromethane / 20 °C

With thionyl chloride; triethylamine; 2-hydroxy-2-methylpropanenitrile; In tetrahydrofuran; dichloromethane; chloroform; 3: |Fries Phenol Ester Rearrangement;
DOI:10.1021/jf5048089