2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

Base Information

• Chemical Name: 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid
• CAS No.: 1613317-17-1
• Molecular Formula: C₂₇H₃₀N₂O₅S₂
• Molecular Weight: 526.678

Synonyms:2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

Chemical Property of 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

Chemical Property:

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Technology Process of 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid

There total 3 articles about 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-[4-(1,1-dioxotetrahydro-1λ6-thiophen-3-yl)thiazol-2-yl]naphthalen-2-ylamine (1613317-32-0) + 2-Cyclohexylbutandisaeure-anhydrid (5962-96-9) → 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid (1613317-17-1)

Guidance literature:

In chloroform; at 65 ℃; for 2h; Inert atmosphere;

Reference yield:

2-(7-bromonaphthalen-2-yl)-4-(1,1-dioxotetrahydro-1λ6-thiophen-3-yl)-thiazole hydrobromide (1613219-86-5) → 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid (1613317-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzophenoneimine; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; sodium t-butanolate / toluene / 90 °C / Inert atmosphere

2: chloroform / 2 h / 65 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; benzophenoneimine; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; In chloroform; toluene;

Reference yield:

2-cyclohexylsuccinic acid (1489-63-0) → 2-cyclohexyl-N-{7-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)thiazol-2-yl]naphthalen-2-yl}succinamic acid (1613317-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / 130 °C / Inert atmosphere

2: chloroform / 2 h / 65 °C / Inert atmosphere

With acetic anhydride; In chloroform;

upstream raw materials:

7-[4-(1,1-dioxotetrahydro-1λ⁶-thiophen-3-yl)thiazol-2-yl]naphthalen-2-ylamine

2-Cyclohexylbutandisaeure-anhydrid

2-cyclohexylsuccinic acid

2-(7-bromonaphthalen-2-yl)-4-(1,1-dioxotetrahydro-1λ⁶-thiophen-3-yl)-thiazole hydrobromide

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