3-nitrophenyl β-chloroethyl sulphone

Base Information

• Chemical Name: 3-nitrophenyl β-chloroethyl sulphone
• CAS No.: 77281-39-1
• Molecular Formula: C₈H₈ClNO₄S
• Molecular Weight: 249.675
• Mol file: 77281-39-1.mol

Synonyms:3-nitrophenyl β-chloroethyl sulphone

Chemical Property of 3-nitrophenyl β-chloroethyl sulphone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-nitrophenyl β-chloroethyl sulphone

There total 2 articles about 3-nitrophenyl β-chloroethyl sulphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloroethyl phenyl sulfone (938-09-0) → 3-nitrophenyl β-chloroethyl sulphone (77281-39-1)

Guidance literature:

With sulfuric acid; nitric acid; at 80 ℃; for 2h;

DOI:10.1002/poc.610071002

Reference yield:

2-(phenylsulfonyl)ethanol (20611-21-6) → 3-nitrophenyl β-chloroethyl sulphone (77281-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: sulfuric acid; nitric acid

With thionyl chloride; sulfuric acid; nitric acid;

Reference yield:

3-nitrophenyl β-chloroethyl sulphone (77281-39-1) → (3-nitrophenyl)vinylsulfone (78735-19-0)

Guidance literature:

With triethylamine; In acetonitrile; at 25 ℃; Rate constant; different amines;

DOI:10.1002/poc.610071002

upstream raw materials:

2-chloroethyl phenyl sulfone

2-(phenylsulfonyl)ethanol

Downstream raw materials:

(3-nitrophenyl)vinylsulfone

3-(2-chloro-ethanesulfonyl)-aniline